Rely on fast, accurate quantification of DNA, RNA and protein samples using only 1–2 μL with Thermo Scientific™ NanoDrop™ microvolume instruments. No dilutions needed even for highly concentrated samples with pioneering sample-retention technology using optical measurement pedestals.

For over 20 years and with over 55,000 citations, NanoDrop instruments have been helping scientists around the world do their best work. With preconfigured methods for common life science applications, NanoDrop instruments make a novice perform like an expert.

It’s as simple as: pipette, measure, know.

NanoDrop One/One^C

Intelligent analysis, streamlined workflows

• Contaminant identification and corrected concentrations with Thermo Scientific™ Acclaro™ Sample Intelligence technology
• Touchscreen interface with guided troubleshooting and pre-programmed methods for life sciences
• Modern connectivity allows seamless data transfer to PC or network via Wi-Fi, USB, or Ethernet. Export data to Thermo Fisher™ Connect cloud-based storage and access it anytime, anywhere from any device!

NanoDrop Eight

Advanced analysis, 8 samples at once

• Measure 8 samples at a time for improved efficiency
• Acclaro Sample Intelligence technology identifies contaminants in your sample
• Pharma ready with 21 CFR Part 11 compliance software and LIMS integration

NanoDrop Lite Plus

Simple analysis, compact design

• Affordable choice for fast, easy measurements
• Measures purified DNA, RNA, and protein concentration up to 30 Abs
• Calculates critical A260/A280 and A260/A230 purity ratios
• Portable instrument requires no PC control
• Optional docking printer prints cryogenic labels

Which NanoDrop instrument should you choose?

	NanoDrop One/OneC UV-Vis	NanoDrop Eight UV-Vis	NanoDrop Lite Plus UV
Product summary	Full-spectrum microvolume UV-Vis measurements with a cuvette option in a single instrument	High-throughput, full-spectrum microvolume UV-Vis measurements	Basic microvolume UV measurements
Sampling options	NanoDrop One: Pedestal only NanoDrop OneC: Pedestal and Cuvette	Pedestal	Pedestal
Measures 1–2 µL sample	Y	Y	Y
Dynamic range	2.0–27,500*	2.0–10,000	2–1,500
(ng/µL dsDNA)	ng/µL for dsDNA	ng/µL for dsDNA	ng/µL for dsDNA
Full-spectra data	Y	Y	N
Pre-programmed methods for nucleic acids and proteins	Y	Y	Y
Measures nucleic acid A260	Y	Y	Y
Measures nucleic acid A260/A280 ratio	Y	Y	Y
Measures nucleic acid A260/A230 ratio	Y	Y	Y
Measures purified protein A280	Y	Y	Y
Measures protein and peptides at A205	Y	Y	N
Measures protein A260/A280 ratio	Y	Y	Y
Pre-programmed methods for colorimetric assays (BCA, Bradford, Lowry, Pierce 660)	Y	Y	N
Custom methods	Y	Y	N
Built-in cuvette option	Y (NanoDrop One^C)	N	N
Standalone local control	Y	Requires computer	Y
High-resolution touchscreen interface	Y	N	Y
Measures fluorescent-labeled nucleic acid and protein samples using absorbance	Y	Y	N
Autoblank and Automeasure	Y	Y	N
Acclaro contaminant identification	Y	Y	N
21 CFR Part 11 regulatory compliance	Optional Security Suite Software	Optional SciVault Software	N
Password-protected access	Optional Security Suite Software	Optional SciVault Software	N
Embedded technical support **	Y	Y	N
Enhanced connectivity (Wi-Fi and Bluetooth™)	Y	N	N
Thermo Fisher Connect (cloud enabled)	Y	N	N

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Technical Specifications

Description	NanoDrop One/OneC Spectrophotometer	NanoDrop Eight Spectrophotometer	NanoDrop Lite Plus Spectrophotometer
Instrument Control	Built-in touchscreen or computer software	Computer software	Built-in touchscreen
Minimum Sample Size	1 µL	1 μL	1 μL
Sample Number	1	Up to 8	1
Pathlength(s)	0.030 to 1.0 mm auto-ranging	1.0, 0.2, 0.1 mm, auto-ranging	1.0 mm and 0.2 mm (auto-ranging)
Light Source(s)	Xenon flash lamp	Xenon flashlamp	Xenon flashlamp
Excitation Maxima of LEDs	N/A	N/A	N/A
Detector Type	2048-element CMOS linear image sensor	2048-element CMOS linear image sensor	2048-element CMOS linear image sensor
Wavelength Range	190–850 nm	190–850 nm	230 nm, 260 nm, 280 nm
Wavelength Accuracy	±1 nm	±1 nm	± 1 nm
Spectral Resolution	≤1.8 nm (FWHM at Hg 254 nm)	≤ 1.8 nm (FWHM at Hg 254 nm)	≤ 1.8 nm (FWHM at Hg 254 nm)
Typical Measurement Repeatability	0.002 A (1.0 mm path) or 1% CV, whichever is greater	0.002 A (1.0 mm path) or 1% CV, whichever is greater*	Typical: 0.002 A (1.0 mm path) or 1%CV, whichever is greater*
Absorbance Accuracy**	3% (at 0.97 A, 302 nm)	3% at 0.97 A, 302 nm, 23 ± 2 C°	3% at 0.97 A, 302 nm, 23 ± 2C°
Absorbance Range (10 mm equivalent)	Pedestal: 0–550A, Cuvette: 0–1.5A	0.04–200 Abs (10 mm equivalent)	0.04–30 Abs (10 mm equivalent)
Lower Limit of Detection	Pedestal: 2 ng/μL (dsDNA) 0.06 mg/mL (BSA) Cuvette: 0.2 ng/μL (dsDNA) 0.006 mg/mL (BSA)	2.0 ng/µL (dsDNA) 1.6 ng/µL (RNA) 0.06 mg/mL (BSA) 0.03 mg/mL (IgG)	2.0 ng/µL (1.6 ng/µL) dsDNA (RNA) 0.06 mg/mL (0.03 mg/mL) BSA. (lgG)
Maximum Concentration	Pedestal: 27,500 ng/μL (dsDNA) 820 mg/mL (BSA)	10,000 ng/µL (dsDNA) 8,000 ng/µL (RNA) 300 mg/mL (BSA) 145 mg/mL (IgG)	1,500 ng/µL (1,200 ng/µL) dsDNA (RNA) 45 mg/mL (21 mg/mL) BSA (lgG)
Measurement and Data Processing Time	8 seconds	< 20 seconds	≤ 5 seconds
21 CFR Part 11 Compliance	Yes	Yes	No
Footprint	20 × 25.4 × 32.3 cm (wdh)	24 cm x 33 cm x 17 cm (wdh)	27 cm x 22 cm x 22 cm (wdh)
Weight	3.6 kg	3.7 kg	2.7 kg (no printer). 3.2 kg (printer)
Sample Pedestal	303 stainless steel and quartz fiber	303 stainless steel and quartz fiber	303 stainless steel and quartz fiber
Cuvette Position	Optional (with stirring)	N/A	N/A
Operating Voltage	12 V (DC)	12 V (DC)	12 V (DC)
Operating Power Consumption	12–18 W	15 W	18 W
Standby Power Consumption	5 W	3 W	< 3 W
Software Compatibility	Standalone control. PC Software: Windows 10 Professional (64 bit)	Windows 10 Version 1607 Professional or Enterprise	Standalone control with data export via USB Flash Drive
Advanced Connectivity	NanoDrop One Cloud Application Thermo Fisher Connect Platform	USB 3.0 port	USB 2.0 Port